I would be very happy if Lego starts doing one large Simpsons set per year, as they've done with LOTR. I agree that a remake of the Simpsons house is a risk, but I would love to see just new sets, starting with Krusty Burger and Springfield Elementary.
I'd also be all in on a new CMF series to help populate our growing town of Springfield - I'm still holding out hope for a Dr Nick figure!